Cold-pressed black seed oil studied in a 2024 PCOS clinical trial. Targets the inflammation your fertility medication can't reach. Works alongside your current protocol.
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Every fertility treatment you've tried operates somewhere in the middle of this chain. Nothing you've been given reaches the bottom.
Letrozole gets you to ovulate. Inositol supports your insulin. Neither one reaches the inflammation driving the whole chain.
Your medications work above the inflammatory root (NF-κB) that's driving everything. Thymoquinone calms that root — a foundation for your stack, not a replacement.
114 PCOS patients. 16 weeks. Improved cycle regularity, lower testosterone, reduced ovarian volume. Published in the Journal of Ovarian Research.
Works with letrozole, Clomid, metformin, inositol, CoQ10, and your prenatal. One ingredient, no interference.
High TQ Black Seed Oil by Loomi
586 clinicians share this on FrontrowMD without compensation.
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Our high-TQ black seed oil works on the inflammation underneath PCOS — so support shows up where you actually feel it:
Every PCOS fix you've tried does the same thing.
It chases a symptom.
The pill, metformin, spearmint tea, cutting carbs, the endless supplement stack.
Different tools, same approach. But none of them touch the reason the symptoms keep coming back.
Underneath PCOS is chronic, low-grade inflammation. It's what feeds the insulin resistance — and the insulin resistance is what pushes your body to overproduce androgens, the hormones behind the weight, the skin, the hair, and the cycles that won't cooperate.
The pill smooths your cycle and calms your skin while you're on it. The moment you stop, it all comes back — because the inflammation underneath was never addressed.
Metformin works on your blood sugar. Helpful for some — but it's aimed downstream of the real problem, and the bloating and stomach issues send a lot of women looking for something gentler.
Spearmint tea, inositol, the half-finished bottles in your cabinet. Each one targets a single piece. None of them quiet the inflammation feeding all of it.
And cutting carbs harder and harder? You white-knuckle it, the scale barely moves, and you're left feeling like your body is broken — when it's actually doing exactly what an inflamed, insulin-resistant body does.
So the question isn't "which symptom do I treat next?"
The question is: what's feeding all of them at once?
That's the layer high-TQ black seed oil is made to work on.
What if you calmed the root — instead of chasing each symptom?
This is where it gets interesting.
There's a reason black seed (Nigella sativa) oil has been used in traditional medicine for over 2,000 years — and why it's suddenly everywhere again.
Its power comes down to one compound: thymoquinone, or TQ.
TQ has been studied for its effect on NF-κB — one of the body's main "inflammation switches." When that switch is stuck on, it drives the chronic, low-grade inflammation that sits underneath PCOS.
And that inflammation is the first domino. It feeds the insulin resistance. The insulin resistance pushes your body to overproduce androgens — the hormones behind the weight, the skin, the hair, and the cycles that won't settle.
Our formula is built around high-TQ oil — concentrated for the active compound and cold-pressed so it stays intact — to support the body at that inflammation layer, instead of masking one symptom at a time.
Because it works on the root layer rather than forcing a single hormone up or down, it supports your whole system gently — without the on-it, off-it whiplash of options that only work while you keep taking them.
Most women notice changes gradually over weeks, not overnight — often steadier energy first, then skin and cycle as the inflammation settles with consistent daily use.
Made for the woman who's done trying everything.
If you're trying to conceive and PCOS is in the way — the irregular or missing cycles, never knowing if or when you ovulate, the negative tests month after month — you're not imagining how hard this is. PCOS is the most common reason for this kind of cycle disruption, and it traces back to the same root: the inflammation and insulin resistance throwing your hormones off balance. Supporting that root is about helping your body find its own rhythm again, which is the foundation a regular cycle is built on.
If you've fought facial or body hair for years — the secret 4 a.m. shave, tweezers stashed in every bag, the small meltdown when you forget a razor — this works on the hormonal driver underneath the hair, not just the surface. It supports the body at the inflammation-and-androgen layer that makes hormonal hair so stubborn in the first place.
If the scale won't move no matter what you do — you eat less than your friends, you do everything "right," and it barely budges. It was never your willpower. An inflamed, insulin-resistant body holds on to weight, and this is made to support that exact layer.
If hormonal acne keeps flaring along your jaw and chin — the deep, cyclical breakouts that no face wash ever touched because they were never really a skin problem. They're downstream of the same root.
If your cycle does whatever it wants — twelve periods in seven months, or none for months — the unpredictability that runs your whole life. Supporting the root helps the body find a steadier rhythm over time.
If you've spent years being dismissed — told it's "just stress," "just lose weight," or all in your head — you're not crazy and you're not alone. This was built for the women that advice failed.
If you're burned out on the pill and metformin — tired of side effects and of fixes that only work while you're on them — this is the gentle, root-layer option a lot of women look for next.
Here's what most women discover: you don't have just one problem. The woman fighting chin hair is also fighting the weight, the breakouts, and the cycle. They all trace back to the same root — the inflammation feeding the whole picture. That's why working on that one layer, consistently, day after day, is what moves everything at once. Give it a full 90 days and treat the cause, not the symptoms one at a time.
No — and the difference is the entire reason most black seed oil does nothing.
The active compound that matters is thymoquinone (TQ) — and it's fragile. It's sensitive to heat, light, and air. The moment you push the seeds through a hot industrial press, most of the TQ degrades.
That's how the cheap stuff is made: high-heat extraction, because it's faster and squeezes more oil out of every batch. You end up with a bottle that smells right and looks right — but barely has enough active TQ left to do anything.
Ours is cold-pressed from the raw seed and concentrated for high TQ. Cold-pressing costs more and yields less oil per batch — but it protects the active compound at full strength, which is the whole point.
That's why our oil works and the bargain-bin versions don't. It was never about the plant. It's about what's actually left in the bottle after extraction.
Cold-pressed. High-TQ. Third-party tested. Trusted by thousands of women who'd already tried the rest.
One ingredient. Nothing to hide behind.
Cold-pressed and standardized to a guaranteed 2% thymoquinone — the active compound that actually matters. No fillers, no proprietary-blend hiding, no padding the label with a dozen "support" ingredients at doses too small to count.
"My period came back on its own for the first time in over a year."
Three rounds of letrozole, two years of tracking, and nothing. I added this alongside my inositol and by week 8 my cycle shortened from 60+ days to 34. I actually ovulated without medication. I'm still in shock… Read more
"My ovulation strips finally turned positive without medication."
I'd been testing every single day for months and never once got a clear positive. Started Loomi alongside my CoQ10 and prenatal. Week 7 — two dark lines. I tested again an hour later because I didn't believe it. Still positive… Read more
"For the girls crying in the fertility clinic parking lot — please try this."
Four IUIs. Two years of letrozole. $9,000 spent. I read the 2024 study and thought what do I have to lose. Three months later my cycles are regular for the first time since I was a teenager. I wish someone had told me about this sooner… Read more
"I'm an engineer. I read the RCT before I bought it. The data is real."
I don't buy supplements based on influencer hype. I pulled the actual study, read the methodology, checked the sample size. Then I tried it. My anovulatory cycles have stabilized for the first time in three years. This is what evidence-based actually looks like… Read more
"My husband asked why I was crying. I handed him the OPK."
Three years of trying. Metformin, inositol, two rounds of Clomid. Nothing. I added Loomi and kept everything else the same. By month 3 my husband found me on the bathroom floor holding a positive ovulation test and sobbing happy tears… Read more
The Results Speak for Themselves
Women who spent years being told their infertility was "unexplained" or that surgery and IVF were their only options are finally seeing what happens when the inflammation gets addressed.
"Two failed IVF cycles. 'Unexplained' infertility. My RE finally ran a BCL6 test and it came back positive. I added this to my protocol 10 weeks before my next transfer. My RE said my lining looked better than it had in any previous cycle. I'm not saying it was the only thing. I'm saying it was the missing thing."
"I had excision surgery two years ago. Was told I'd be pregnant in 6 months. It's been 22 months. 16 weeks on this and my cycles are finally feeling like my body isn't fighting itself. I'm not pregnant yet — but for the first time in two years, I don't feel like the surgery was pointless."
"I spent 10 years being told my pain was 'just bad periods.' By the time someone finally said the word endometriosis I was 31 and couldn't get pregnant. 8 supplement bottles on my counter. Every fertility protocol in the book. This was the first thing that felt like it was actually targeting the root cause instead of working around it."
Surgery removes the lesions. IVF bypasses the damage. Black cumin seed oil addresses the NF-κB inflammatory cascade compromising egg quality and uterine receptivity — backed by a 2024 randomized controlled trial on 114 women with a related inflammatory-hormonal condition.
Cold-pressed, no fillers, no carrier oils, no dilution
Every batch tested for thymoquinone potency
Published 2024 RCT — 16-week protocol, 114 women, peer-reviewed
Won't interfere with IVF cycles, transfers, or hormonal pretreatment
Common Questions
Everything women trying to conceive with PCOS want to know before adding high-TQ black cumin seed oil.
No. Thymoquinone works on the NF-κB inflammatory cascade — the upstream environment your follicles develop in. Letrozole and Clomid work by forcing the hormonal signal that triggers ovulation. Metformin works on insulin sensitivity. They target completely different systems. It's safe to take alongside ovulation-induction protocols, metformin, spironolactone, and inositol. Most of our TTC customers use it as the foundation underneath whatever their RE already has them on.
Many customers notice skin and oiliness changes within 2-4 weeks. Cycle-related changes — more predictable cycle length, clearer signs of ovulation — typically take longer because your body works on its own timeline. The clinical trial measured significant improvements in hormonal balance, ovarian morphology, and menstrual regularity at 16 weeks. We recommend committing to at least 8-12 weeks before re-testing labs or judging your cycle pattern.
Yes — and they complement each other. Inositol improves insulin signaling at the cellular level. Thymoquinone suppresses the NF-κB inflammatory cascade upstream of insulin resistance — the same inflammation that's been studied for its effect on the follicular environment. They work on different parts of the same problem. Many of our customers take both and report better results than either alone.
Nigella sativa has been used for centuries and has a strong safety profile, and the 2024 trial reported improved hormonal balance and cycle regularity. That said, when you are actively trying to conceive, we always recommend running any new supplement past your OB-GYN or reproductive endocrinologist first — especially if you're mid-protocol. This is a foundation for a healthier ovulatory environment, not a substitute for the care your fertility team is providing.
Our Nigella sativa is sourced from the regions where it has been traditionally cultivated for centuries — primarily Egypt and Turkey, where the soil and climate produce the highest natural thymoquinone concentrations. The oil is cold-pressed at the source to preserve the active compound, then formulated, encapsulated, and third-party tested in the USA. Every batch is verified to meet our 2% TQ standardization before it ships.
Most generic black seed oil contains less than 1% thymoquinone — the active compound behind the clinical results. Ours is standardized to 2% TQ, verified by third-party testing. The concentration matters. It's the difference between drinking grape juice and taking the active compound.
90-day money-back guarantee. The clinical trial ran for 16 weeks — we give you 90 days so you have time to take it consistently and let your cycle respond. If you're not satisfied, contact us for a full refund. No questions asked.
"Two failed letrozole cycles. An RE who kept saying I just wasn't ovulating. After years of nothing on its own, my period came back without a single pill — and the ovulation strips finally went positive. I'm not promising anyone anything, but my body is back in the game and that's everything right now."
For most women with PCOS, infertility isn't a hormone problem you can simply override. It's an ovulation problem — and ovulation is downstream of the inflammatory environment your follicles are trying to develop in. That's the piece letrozole and Clomid don't touch. They push the signal; they don't change the soil.
In 2024, researchers published a randomized controlled trial on 114 adolescents with PCOS. After 16 weeks, the Nigella sativa group showed reduced ovarian volume, lower testosterone, an improved LH-to-FSH ratio, and more regular menstrual cycles — the markers of a healthier ovulatory environment — with results comparable to medroxyprogesterone, a standard pharmaceutical treatment.
"Nigella sativa demonstrated comparable efficacy to medroxyprogesterone in improving menstrual regularity, hormonal balance, and ovarian morphology in adolescents with polycystic ovary syndrome."
— Journal of Ovarian Research, 2024
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Cold-pressed Nigella sativa, standardized to 2% thymoquinone, third-party tested for purity and potency. The one compound studied for its effect on the inflammatory environment your fertility meds were never designed to address. Delivered to your door with a 90-day money-back guarantee.
Shop NowSee what our PCOS fertility customers are saying about our formula
i have PCOS and we'd been trying for a baby for almost two years. did two rounds of letrozole, no response, my RE basically told me i wasn't ovulating and the next step was injectables we couldn't afford. i'd given up on my body doing anything on its own. started this in february. march — nothing. april — a period, by itself, no provera, no nothing. then another one 31 days later. i sat on the bathroom floor staring at the ovulation strip drawer. three cycles in a row now my body has shown up on its own and i can actually SEE when i'm ovulating instead of guessing. i'm not promising anyone anything. but i finally feel like my body is back in the game.
two years of TTC with PCOS. every single month i'd pee on an ovulation strip and the line stayed faint. faint. faint. my RE said i probably wasn't ovulating regularly because of the PCOS and that's the whole reason nothing was happening. i'd read about the thymoquinone study so i figured what's another bottle. week 6 i got the first clear positive strip i have ever seen in my life. blazing dark. i texted a photo of it to my best friend at 6 in the morning. nothing about TTC is guaranteed and i know that better than anyone — but watching that line finally go dark felt like my body remembered what it's supposed to do.
if you have PCOS and you're trying to conceive then you already know the exact kind of exhaustion i'm talking about. the appointments. the "just lose weight" from doctors who don't get it. the cycles that never come so you can't even time anything. i'm not going to oversell this because i hate when people do that. but my cycles went from completely random to roughly 30-32 days within about 10 weeks, and for the first time i could actually predict a fertile window. my skin calmed down, the dark chin hairs slowed way down — those are real hormonal markers, not in my head. i'm still on this road but i walked into my last RE appointment with actual data instead of dread for once.
i don't buy supplements on vibes. i'm an engineer and i read the actual 2024 trial before i spent a single dollar. standardized 2% TQ versus the sub-1% stuff all over amazon — that distinction is real and it matters. i have PCOS with anovulatory cycles, which is exactly why we hadn't been able to conceive — you can't get pregnant in a month you don't ovulate. i'm 11 weeks in now. my cycle length has stabilized into a window i can finally predict for the first time since high school, and i'm getting positive OPKs i never used to get. it's doing the thing the data said it might do, which is all i was asking for.
married 4 years, PCOS diagnosis, trying for most of that time. i'd genuinely stopped expecting my period to show up without medication, which meant i'd stopped expecting to ovulate at all. and then it just did. day 33. then it came again. my husband walked into the bathroom and i was crying and he completely panicked until i explained they were the good kind of tears. i'm not going to pretend a bottle is a miracle and i won't insult you like that. but having a cycle i can track again, feeling like ovulation is even on the table after years of nothing — that's hope i did not have last spring, and right now that's worth everything to me.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results may vary from person to person. Consult your healthcare provider before starting any new supplement, especially if you are pregnant, nursing, trying to conceive, or taking medication.
